Browsing by Author "Gopalakrishnan, Ramakrishna Prabhu"

Now showing items 1-6 of 6

  • Antigen bivalency of antigen-presenting cell-targeted vaccines increases B cell responses 
    Hinke, Daniëla Maria; Andersen, Tor Kristian; Gopalakrishnan, Ramakrishna Prabhu; Skullerud, Lise Madelene; Werninghaus, Ina Charlotta; Grødeland, Gunnveig; Fossum, Even; Braathen, Ranveig; Bogen, Bjarne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Antibodies are important for vaccine efficacy. Targeting antigens to antigen-presenting cells (APCs) increases antibody levels. Here, we explore the role of antigen valency in MHC class II (MHCII)-targeted vaccines delivered ...
  • B cell receptor ligation induces display of V-region peptides on MHC class II molecules to T cells 
    Huszthy, Peter Csaba; Gopalakrishnan, Ramakrishna Prabhu; Jacobsen, Johanne Tracey; Haabeth, Ole Audun; Løset, Geir Åge; Braathen, Ranveig; Schenck, Karl; Tveita, Anders Aune; Munthe, Ludvig Andre; Bogen, Bjarne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    The B cell receptors (BCRs) for antigen express variable (V) regions that are enormously diverse, thus serving as markers on individual B cells. V region-derived idiotypic (Id) peptides can be displayed as pId:MHCII complexes ...
  • Enhanced germinal center reaction by targeting vaccine antigen to major histocompatibility complex class II molecules 
    Andersen, Tor Kristian; Huszthy, Peter Csaba; Gopalakrishnan, Ramakrishna Prabhu; Jacobsen, Johanne Tracey; Fauskanger, Marte; Tveita, Anders Aune; Grødeland, Gunnveig; Bogen, Bjarne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Enhancing the germinal center (GC) reaction is a prime objective in vaccine development. Targeting of antigen to MHCII on APCs has previously been shown to increase antibody responses, but the underlying mechanism has been ...
  • Id-neoantigen vaccine induces therapeutic CD8+ T cells against multiple myeloma: H chain-loss escapees cause FLC MM 
    Westhrin, Marita; Blazevski, Jana; Textor, Ana; Abdollahi, Pegah; Gopalakrishnan, Ramakrishna Prabhu; Ngo, Linda Thuy; Hofgaard, Peter Olaf; Heinzelbecker, Julia; Bobic, Sonja; Fossum, Even; Spång, Heidi Cecilie Larsen; Braathen, Ranveig; Bogen, Bjarne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2023)
    Background Multiple myeloma (MM) cancers originate from plasma cells that have passed through the germinal center reaction where somatic hypermutation of Ig V regions takes place. Myeloma protein V regions often express ...
  • Reduced MCMV Δm157 viral clearance in the absence of TSAd 
    Moussa, P; Abrahamsen, Greger; Fodil, N; Gopalakrishnan, Ramakrishna Prabhu; Mancini, M; Dissen, Erik; Sæther, Per Christian; Wiltshire, SA; Boivin, GA; Caignard, G; Spurkland, Anne; Vidal, SM (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2015)
    The T cell specific adapter protein (TSAd) is expressed in activated T cells and NK cells. While TSAd is beginning to emerge as a critical regulator of Lck and Itk activity in T cells, its role in NK cells has not yet been ...
  • The SH3 domains of the protein kinases ITK and LCK compete for adjacent sites on T cell?specific adapter protein 
    Andersen, Thorny Cesilie Bie; Kristiansen, Per Eugen; Huszenicza, Zsuzsa; Johansson, Maria U.; Gopalakrishnan, Ramakrishna Prabhu; Kjelstrup, Hanna; Boyken, Scott; Gjerstad, Vibeke Sundvold; Granum, Stine; Sørlie, Morten; Backe, Paul Hoff; Fulton, Bruce D; Karlsson, B.Göran; Andreotti, Amy H.; Spurkland, Anne (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
    T-cell activation requires stimulation of specific intracellular signaling pathways in which protein-tyrosine kinases, phosphatases, and adapter proteins interact to transmit signals from the T-cell receptor to the nucleus. ...