Browsing by Author "Chen, Xin"

Now showing items 1-5 of 5

  • Epigenetic–smoking interaction reveals histologically heterogeneous effects of TRIM27 DNA methylation on overall survival among early-stage NSCLC patients 
    Ji, Xinyu; Lin, Lijuan; Shen, Sipeng; Dong, Xuesi; Chen, Chao; Li, Yi; Zhu, Ying; Huang, Hui; Chen, Jiajin; Chen, Xin; Wei, Liangmin; He, Jieyu; Duan, Weiwei; Su, Li; Jiang, Yue; Fan, Juanjuan; Guan, Jinxing; You, Dongfang; Shafer, Andrea; Bjaanæs, Maria Moksnes; Karlsson, Anna; Planck, Maria; Staaf, Johan; Helland, Åslaug; Esteller, Manel; Wei, Yongyue; Zhang, Ruyang; Chen, Feng; Christiani, David C. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Tripartite motif containing 27 (TRIM27) is highly expressed in lung cancer, including non‐small‐cell lung cancer (NSCLC). Here, we profiled DNA methylation of lung adenocarcinoma (LUAD) and lung squamous cell carcinoma ...
  • Epigenome-wide gene-age interaction analysis reveals reversed effects of PRODH DNA methylation on survival between young and elderly early-stage NSCLC patients 
    Chen, Chao; Wei, Yongyue; Wei, Liangmin; Chen, Jiajin; Chen, Xin; Dong, Xuesi; He, Jieyu; Lin, Lijuan; Zhu, Ying; Huang, Hui; You, Dongfang; Lai, Linjing; Shen, Sipeng; Duan, Weiwei; Su, Li; Shafer, Andrea; Fleischer, Thomas; Bjaanæs, Maria Moksnes; Karlsson, Anna; Planck, Maria; Wang, Rui; Staaf, Johan; Helland, Åslaug; Esteller, Manel; Zhang, Ruyang; Chen, Feng; Christiani, David C. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    DNA methylation changes during aging, but it remains unclear whether the effect of DNA methylation on lung cancer survival varies with age. Such an effect could decrease prediction accuracy and treatment efficacy. We ...
  • Independent validation of early-stage non-small cell lung cancer prognostic scores incorporating epigenetic and transcriptional biomarkers with gene-gene interactions and main effects 
    Zhang, Ruyang; Chen, Chao; Dong, Xuesi; Shen, Sipeng; Lai, Linjing; He, Jieyu; You, Dongfang; Lin, Lijuan; Zhu, Ying; Huang, Hui; Chen, Jiajin; Wei, Liangmin; Chen, Xin; Li, Yi; Guo, Yichen; Duan, Weiwei; Liu, Liya; Su, Li; Shafer, Andrea; Fleischer, Thomas; Bjaanæs, Maria Moksnes; Karlsson, Anna; Planck, Maria; Wang, Rui; Staaf, Johan; Helland, Åslaug; Esteller, Manel; Wei, Yongyue; Chen, Feng; Christiani, David C. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Background DNA methylation and gene expression are promising biomarkers of various cancers, including non-small cell lung cancer (NSCLC). Besides the main effects of biomarkers, the progression of complex diseases is ...
  • On the sources and sinks of atmospheric VOCs: an integratedanalysis of recent aircraft campaigns over North America 
    Chen, Xin; Millet, Dylan B.; Singh, Hanwant B.; Wisthaler, Armin; Apel, Eric C.; Atlas, Elliot L.; Blake, Donald R.; Bourgeois, Ilann; Brown, Steven S.; Crounse, John D.; de Gouw, Joost A.; Flocke, Frank M.; Fried, Alan; Heikes, Brian G.; Hornbrook, Rebecca S.; Mikoviny, Tomas; Min, Kyung-Eun; Müller, Markus; Neuman, J. Andrew; O’Sullivan, Daniel W.; Peischl, Jeff; Pfister, Gabriele G.; Richter, Dirk; Roberts, James M.; Ryerson, Thomas B.; Shertz, Stephen R.; Thompson, Chelsea R.; Treadaway, Victoria; Veres, Patrick R.; Walega, James; Warneke, Carsten; Washenfelder, Rebecca A.; Weibring, Petter K.A.; Yuan, Bin (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    We apply a high-resolution chemical transport model (GEOS-Chem CTM) with updated treatment of volatile organic compounds (VOCs) and a comprehensive suite of airborne datasets over North America to (i) characterize the VOC ...
  • SIPA1L3 methylation modifies the benefit of smoking cessation on lung adenocarcinoma survival: an epigenomic-smoking interaction analysis 
    Zhang, Ruyang; Lai, Linjing; Dong, Xuesi; He, Jieyu; You, Dongfang; Chen, Chao; Lin, Lijuan; Zhu, Ying; Huang, Hui; Shen, Sipeng; Wei, Liangmin; Chen, Xin; Guo, Yichen; Liu, Liya; Su, Li; Shafer, Andrea; Moran, Sebastian; Fleischer, Thomas; Bjaanæs, Maria Moksnes; Karlsson, Anna; Planck, Maria; Staaf, Johan; Helland, Åslaug; Esteller, Manel; Wei, Yongyue; Chen, Feng; Christiani, David C. (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Smoking cessation prolongs survival and decreases mortality of patients with non‐small‐cell lung cancer (NSCLC). In addition, epigenetic alterations of some genes are associated with survival. However, potential interactions ...