Browsing by Author "Chen, Wenlin"

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  • Anticarin-β shows a promising anti-osteosarcoma effect by specifically inhibiting CCT4 to impair proteostasis 
    Wang, Gan; Zhang, Min; Meng, Ping; Long, Chengbo; Luo, Xiaodong; Yang, Xingwei; Wang, Yunfei; Zhang, Zhiye; Mwangi, James; Kamau, Peter Muiruri; Dai, Zhi; Ke, Zunfu; Zhang, Yi; Chen, Wenlin; Zhao, Xudong; Ge, Fei; Lv, Qiumin; Rong, Mingqiang; Li, Dongsheng; Jin, Yang; Sheng, Xia; Lai, Ren (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Unlike healthy, non-transformed cells, the proteostasis network of cancer cells is taxed to produce proteins involved in tumor development. Cancer cells have a higher dependency on molecular chaperones to maintain proteostasis. ...